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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cimetidine
supplement:
Quinine
Research Papers that Mention the Interaction
“After cimetidine pretreatment there was a significant reduction in the apparent oral clearance of quinine , from 0.182 +/- 0.063 (mean +/- s.d.)”
“The apparent interaction between quinine and cimetidine may have therapeutic implications.”
Effects of cimetidine and ranitidine on the pharmacokinetics of quinine.“The dipyridamole inhibitory effect was nearly comparable with the effect of 1 mM quinine (a typical organic cation transport inhibitor), which led to 95% inhibition of cimetidine renal transport over time.”
Interaction of dipyridamole, a nucleoside transport inhibitor, with the renal transport of organic cations by LLCPK1 cells.“Amiloride, quinidine, and quinine inhibited cimetidine uptake, whereas N1-methylnicotinamide, tetraethylammonium, and guanidine did not.”
“More lipophilic cations such as quinidine and quinine inhibited not only the accumulation of cimetidine but also that of an organic anion, benzylpenicillin, although the inhibitory mechanisms are not known.”
“Uptake of cimetidine by active cationic transport was likely inasmuch as both cyanine 863 and quinine blocked accumulation.”
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