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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Cimetidine
supplement:
Quinidine
Research Papers that Mention the Interaction
“In this study, we show that cimetidine also decreases the bioavailable fraction of quinidine.”
Effect of cimetidine on quinidine bioavailability.“ Cimetidine , a commonly used H2 receptor antagonist, was found to adversely interact with many drugs metabolized by the liver, including class I antiarrhythmic agents, lidocaine and quinidine.”
“ Quinidine and cimetidine similarly inhibited uptake in both strains.”
“Furthermore, cimetidine , azole antifungals and calcium antagonists can significantly inhibit the metabolism of quinidine.”
“This type of drug interaction has been reported after administration of both cimetidine and ranitidine with procainamide or quinidine.”
“…%quinidine … cimetidine (mol/mol), the apparent IC(50) value of cimetidine decreased from 98 µM to 4.4 µM. With the addition of 10% quinidine, the … decrease in apparent IC(50) values can produce a false alert and cause the inappropriate elimination of good compounds at an early stage.”
“ Cimetidine may increase quinidine levels and symptoms of quinidine toxicity.”
“The interaction probably caused by an inhibition of hepatic drug metabolism of quinidine by cimetidine would be most significant in patients with liver disease and in the elderly.”
“ Cimetidine reduced the mean apparent oral clearance of quinidine (+/- s.e.m.)”
“The reduction in quinidine renal clearance associated with cimetidine pre-treatment, although failing to achieve statistical significance, partially accounted for the observed decrease in mean apparent oral clearance.”
“This suggests that cimetidine may compete for renal tubular secretion of unchanged quinidine and its metabolites rather than alter the oxidative metabolism of quinidine.”
“ Cimetidine , a commonly used H2‐receptor antagonist, was found to interact adversely with many drugs, including class I antiarrhythmics such as lidocaine and quinidine.”
“ Cimetidine increased the area under the time-concentration curve (14.5%, p > 0.01), decreased the total body clearance (24.9%, p > 0.05), and prolonged the half-life (22.6%, p > 0.05) of quinidine in this study.”
“Patients placed on cimetidine and quinidine should be monitored closely for signs and symptoms of quinidine toxicity.”
“Theoretically cimetidine could inhibit the metabolism of quinidine.”
“These data document an interaction between cimetidine and quinidine.”
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