supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Cimetidine
supplement:
Glutathione
Research Papers that Mention the Interaction
“ Cimetidine pretreatment also significantly reduced the rate of hepatic glutathione depletion.”
Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man.“NO was significantly decreased, while renal glutathione and cytochrome p450 were significantly increased in groups treated with l-carnitine or cimetidine as compared to group II.”
A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats.“As compared to the cimetidine group, pre‐treatment using either GSH or NAC with Cimetidine produced a marked decrease in lidocaine levels (37 ± 27 and 63 ± 28 ng/mL, respectively) and no modification of MEGX levels (155 ± 12 and 165 ± 22 ng/mL, respectively).”
“These results suggest that GSH and NAC might accelerate the lidocaine metabolism while counteracting the inhibitory effect of Cimetidine.”
“Also the glutathione concentration was lower in cimetidine treated cells [15.2 versus 15.9 nmol/10(6) cells] (P < 0.05).”
“ Cimetidine decreased the rate of hepatic glutathione depletion and acetaminophen covalent binding in vivo in a dose-dependent manner whereas only a high dose of N-acetylcysteine decreased covalent binding.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback