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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Cimetidine and Ferrous Sulfate

Research Papers that Mention the Interaction

ferrous sulfate … cimetidine (300 mg) was associated with little reduction in serum cimetidine area under the curve (AUC) (mean versus mean, 20.8 versus 23.4 … concentration (Cmax) (mean versus mean, 5.1 versus 6.1 mumol/L; mean percentage difference, -16%; CI of percentage difference, -36% to 4%).
Clinical pharmacology and therapeutics  •  1996  |  View Paper
The higher ferrous sulfate dose completely inhibited cimetidine absorption (P<0.01), while the lower dose of ferrous sulfate caused a 63% reduction in cimetidine absorption (P<0.05).In vitro iron in its ferrous form rapidly oxidizes to the ferric form.
Digestive Diseases and Sciences  •  1993  |  View Paper