supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
drug:
Cimetidine
supplement:
Epinephrine
Research Papers that Mention the Interaction
“The intravenous administration of cimetidine led to a stransient but moderate drop in the mean blood pressure as well as a delayed appearance of high concentrations of noradrenaline and adrenaline , induced by high concentrations of circulating histamine released with cimetidine.”
Metabolic changes in cimetidine treatment for scald injury on the peritoneo-serosal surface in far-advanced gastric cancer patients treated by intraperitoneal hyperthermic perfusion“The sCr increased but the 24-hour ClCr, MDRD, EPI , and C&G decreased after vs before cimetidine.”
“The effects of epinephrine , histamine, and adenosine were inhibited by the addition of propranolol (a beta-adrenergic antagonist), cimetidine (histamine H2-antagonist), and theophylline (adenosinereceptor antagonist), respectively.”
“ Cim inhibited epinephrine release without affecting the development of hypovolemic shock.”
“Before anesthesia, 200 mg cimetidine decreased plasma epinephrine concentration (E) from 135 +/- 48 (s.e.)”
“Pretreatment with the H2-receptor antagonist cimetidine or the H1-receptor antagonist mepyramine reduced the rise in plasma epinephrine.”
Mechanism of histamine-induced epinephrine release in guinea pig.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback