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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cimetidine
supplement:
Cocaine
Research Papers that Mention the Interaction
“Pretreatment with the P450 inhibitor, cimetidine (Cime, 50 mg/kg) or metyrapone (Mety, 40 mg/kg) abolished or significantly attenuated the effects of cocaine on TNF-α and CPK activity.”
Induction of Cardiac Cytochrome P450 in Cocaine-Treated Mice“When the preexposure time to 48/80 was reduced to 30 s, the facilitation was less pronounced (15%) and inverted to an inhibition in the presence of cocaine (plus idazoxan) by 17% and/or cimetidine (by about 30%).”
“Consistent with the hypothesis that these in vivo protective effects resulted from interaction with cytochrome P450, cimetidine inhibited in vitro hepatic microsomal metabolism of cocaine.”
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