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“In cerebral arteries previously submitted to an active tone, the opioid-induced vasodilation was unchanged by naloxone, cimetidine , diphenhydramine or ouabain, whereas Ca2+ addition antagonized this effect.”
“These results suggest that cimetidine , in doses higher than that required to block cardiac H2-receptors, may have a cardio-stimulating action mediated through increase of inward Ca++ current.”
The Journal of pharmacology and experimental therapeutics • 1986 | View Paper
“Recently cimetidine (Tagamet), a widely used drug for peptic ulcer disease, was found to decrease serum levels of calcium and immunoreactive parathyroid hormone in patients with hyperparathyroidism.”