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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Chymotrypsin
drug:
Substance P
Research Papers that Mention the Interaction
“100 units of substance P (0.5 mg) is completely inactivated by 7 μg chymotrypsin in 25 min.”
Inactivation of substance P by proteolytic enzymes.“ Chymotrypsin reduced mechanical responses to SP but had no effect on responses to field stimulation.”
Non‐cholinergic neurotransmission and the effects of peptides on the urinary bladder of guinea‐pigs and rabbits.“A proteolytic enzyme, chymotrypsin (10 U/ml), antagonised the excitatory effect of substance P , but not that of the non-adrenergic, non-cholinergic excitatory response or ATP.”
“The addition of exogenous peptidases such as pronase, chymotrypsin and an extract of black widow spider venom gland dramatically increased the rate of degradation of SP , shortened the fading response and blocked the development of tachyphylaxis.”
“are reversibly depressed by chymotrypsin , an enzyme which degrades SP , although the responses to acetylcholine, serotonin and an unknown hyperpolarizing transmitter are unaffected.”
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