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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Chymotrypsin
drug:
Colforsin
Research Papers that Mention the Interaction
“In contrast, addition of forskolin during proteolysis with chymotrypsin prevented the time- and concentration-dependent decline in forskolin stimulation observed with chymotrypsin.”
“Proteolysis with chymotrypsin led to a concentration- and time-dependent increase in activation of adenylate cyclase by isoproterenol + guanine nucleotides, and fluoride, and to a decrease in activation by forskolin.”
“Since forskolin is thought to act directly on the catalytic unit of adenylate cyclase, and since forskolin can protect against the effect of proteolysis with chymotrypsin , the site involved may be on the catalytic unit itself.”
Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase.“The binding of [3H]forskolin to rat brain membranes is reduced in membranes that are heated or pretreated with chymotrypsin , trypsin, or N-ethylmaleimide.”
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