Possible Interaction: Chondroitin Sulfates and Heparin

“The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain leading to the deaths of several dozens of patients.”

“The selective and sensitive detection of heparin , an anticoagulant in clinics as well as its contaminant oversulfated chondroitin sulfate ( OSCS ) is of great importance.”

“We demonstrate a highly significant correlation between the concentration of OSCS present in the contaminated heparin and BK released concentration.”

“While the published reports indicated that carryover dermatan sulfate and … this issue, along with other publications, clearly indicate that the OSCS … heparin and other contaminants such as chemically modified heparin byproducts, and carryover heparin From the … Medical School, Ann Arbor, MI (ER); and University of Calgary, Alberta, Canada (RDH).”

“In 2008, certain lots of heparin were associated with anaphylactic like reactions resulting from contamination with oversulphated chondroitin sulphate ( OSCS).”

“ Heparins can be contaminated with oversulfated chondroitin sulfate , OSCS, the impurity being linked to adverse clinical events that certain lots of heparins have had on humans.”

“The reported clinical features of many of the cases further support the conclusion that contamination of heparin with OSCS was the cause of the outbreak.”

“Although FDA has not yet definitively confirmed that heparin was purposefully adulterated with OSCS , it seems likely this is what happened.”

“Through the use of 2 different colorimetric assays and cellulose acetate electrophoresis, we found the following: 1) … of the heparin family; 2) dermatan sulfate is the second most predominant GAG component; 3) chondroitin-6-sulfate is found at … less than the heparins ; and 4) hyaluronan and … only minor constituents.”

“Adulteration attempts of isolated heparin with chondroitin sulfate in the past resulted in great safety concerns.”