Possible Interaction: Chondroitin Sulfates and Glucosamine

“CONCLUSION For patients with or at risk for osteoarthritis, the use of glucosamine and chondroitin sulfate may serve as a nonoperative means to protect joint cartilage and delay osteoarthritis progression.”

“ CONCLUSION For patients with or at risk for osteoarthritis, the use of glucosamine and chondroitin sulfate may serve as a nonoperative means to protect joint cartilage and delay osteoarthritis progression.”

“The … chondroitin sulphate … glucosamine for knee osteoarthritis (OA) is debated, but the suggestion, from analysis of past clinical trials, that a subgroup of patients with moderate to … might benefit from this therapy has now been further explored in the phase IV MOVES (Multicentre Osteoarthritis interVEntion trial with Sysadoa) trial.”

“The synergistic chondroprotective effect of CS and GlcN , firstly reported by our group at the intracellular level, is now demonstrated also at the extracellular level.”

“RESULTS A … therapy of chondroitin sulfate … glucosamine hydrochloride was effective in reducing WOMAC pain by 20% (differences of 23.4%, P=0.006) and 50% (differences of 15.7%, P=0.016), WOMAC pain (P=0.032), WOMAC stiffness (P=0.043), and WOMAC total score (P=0.035).”

“ Glucosamine treatment , which increases UDP-GlcNAc availability and protein O-GlcNAcylation, increased synthesis of both HA and chondroitin sulfate.”

“Moreover, since combined dosing of GlcN with CS was found to reduce the plasma levels seen with GlcN dosing alone, any improved pain relief by combination dosing cannot be explained by higher circulating concentrations of GlcN.”

“Most significantly, the endogenous concentration and CS disaccharide composition were not detectably altered by ingestion of CS, when the CS was … combination with GlcN. On the other hand, the Cmax (single-dose study) and AUC values (multiple-dose study) for ingested GlcN were significantly … dosing with CS , relative … alone. ”

“Most significantly, the endogenous concentration and CS disaccharide composition were not detectably altered by ingestion of CS, when the CS was … combination with GlcN. On the other hand, the Cmax (single-dose study) and AUC values (multiple-dose study) for ingested GlcN were significantly … dosing with CS , relative … alone.”

“ Chondroitin sulfate also appears to reduce osteoarthritis symptoms and is often combined with glucosamine , but there is no reliable evidence that the combination is more effective than either agent alone.”

“For a subset of participants with moderate-to-severe pain, glucosamine combined with chondroitin sulfate provided statistically significant pain relief compared with placebo, about 79% had a 20% or greater reduction in pain versus about 54% for placebo.”

“The … that oral glucosamine … CS may interact in a complementary or synergistic fashion to improve synovial fluid HA content in OA should be assessed in clinical studies, and the potential of adjunctive CS administration to improve the clinical response achievable with optimal intakes of glucosamine should likewise be evaluated.”

“Osteoarthritis: Glucosamine plus chondroitin sulfate : long-term therapy could retard progression of knee OA”