Possible Interaction: Chondroitin Sulfates and Glucosamine

“Furthermore, source materials such as shellfish chitin and fungi for Ga or cartilage from mammals, birds or fish for CS, manufacturing methods, contaminants and so on, can influence biological and pharmacological properties of CS and Ga preparations, as compared to natural GAG that are present in food.”

“The synergistic chondroprotective effect of CS and GlcN , firstly reported by our group at the intracellular level, is now demonstrated also at the extracellular level.”

“Diagnostic work-up of the case revealed no other possible cause of liver injury, and causality assessment using the Roussel Uclaf Causality Assessment Method (RUCAM) resulted in a possible causal relationship between intake of glucosamine and chondroitine sulfate and the adverse hepatic reaction.”

“Moreover, since combined dosing of GlcN with CS was found to reduce the plasma levels seen with GlcN dosing alone, any improved pain relief by combination dosing cannot be explained by higher circulating concentrations of GlcN.”

“Most significantly, the endogenous concentration and CS disaccharide composition were not detectably altered by ingestion of CS, when the CS was … combination with GlcN. On the other hand, the Cmax (single-dose study) and AUC values (multiple-dose study) for ingested GlcN were significantly … dosing with CS , relative … alone.”

“ Chondroitin sulfate also appears to reduce osteoarthritis symptoms and is often combined with glucosamine , but there is no reliable evidence that the combination is more effective than either agent alone.”

“For a subset of participants with moderate-to-severe pain, glucosamine combined with chondroitin sulfate provided statistically significant pain relief compared with placebo, about 79% had a 20% or greater reduction in pain versus about 54% for placebo.”

“The … that oral glucosamine … CS may interact in a complementary or synergistic fashion to improve synovial fluid HA content in OA should be assessed in clinical studies, and the potential of adjunctive CS administration to improve the clinical response achievable with optimal intakes of glucosamine should likewise be evaluated.”

“As an adverse event, it has been reported that anticoagulation activity of warfarin was enhanced by simultaneous intakes of glucosamine and chondroitin sulfate.”

“The effect of GS and CS used in combination was stronger than individual GS and CS, showing a repair property.”

“Isolated Glu decreased CS content though not reaching statistical significance.”