Possible Interaction: Chondroitin Sulfates and Calcium Supplement

“The inhibitory actions of both citrate and chondroitin sulfate were significantly attenuated by increasing calcium concentration from 0.25 mM to 6.0 mM (P less than 0.01).”

“One GAG, chondroitin sulfate , has previously been shown to inhibit calcium oxalate crystal formation.”

“Glycosaminoglycan (GAG) synthesis rates (as measured by incorporation of [14C]-glucosamine or [35S]-sulfate) of the various GAG types secreted into the culture medium (hyaluronic acid, chondroitin sulfate , dermatan sulfate, heparan sulfate) were evenly inhibited by ca.”

“ Chondroitin sulfate prevented calcium accumulation and thus mineralization in these cultures.”

“The lamina is not removed and the cellular alterations do not occur in the absence of hyaluronidase in calcium-free medium or when both enzyme and calcium are present, possibly because digestion of chondroitin sulfate , a component of the lamina, is inhibited by calcium.”

“ Soluble sodium chondroitin sulphate , from bovine ribs or puppy epiphyseal … glucuronate, decreased the amounts of calcium and phosphate precipitated from a solution 6.9mm in phosphate and 6.9 or 13.8mm in ….6-8.2 with 20-25mm-collidine and 5-20mn-hydrochloric acid when incubated for 2hr.”

“Heparin and, to a lesser extent, chondroitin sulfate were found to inhibit calcium oxalate precipitation.”