Possible Interaction: Cholinesterase Inhibitors and Tubocurarine

“They were postulated to explain why the administration of depolarizing agents or anti-cholinesterases cause fasciculations, a sure sign of nerve reaction to the drug, that can be prevented by prior administration of tubocurarine or other nondepolarizing relaxants.”

“It shows less cumulation than pancuronium or tubocurarine , and is easily antagonized by anticholinesterases and aminopyridines.”

“Excitatory junctional potentials are abolished by d-tubocurarine and enhanced by a cholinesterase inhibitor.”

“Earthworm fibers differed from frog sciatic in several respects: they were not made hyper-excitable by calcium depletion; they showed repetitive firing … (the repetitive firing could be antagonized by barbital and trimethadione, not by bromide or diphenylhydantoin); they showed transient lowering of threshold by cholinesterase inhibitors ; catelectrotonic … byd-tubocurarine.”

“Moreover, while the neuromuscular block produced by Dtubocurarine is antagonized by anti-cholinesterases , the decamethonium block is not.”