Possible Interaction: Choline and Vitamin B 12

“Although this relationship does not necessarily mean causality, there are several hypothetical mechanisms by which reduced vitamin B12 may lead to reduced availability of choline as a substrate for cholinergic transmission.”

“Choline supplementation or a combination of choline and vitamin B12 caused an increase in egg production and egg weight, and a decrease in liver fat.”

“In a report from the authors’ laboratory (Welch and Couch, 1955), it was reported that the addition of choline to a diet deficient in methionine increased egg production in the presence of vitamin B12.”

“When sub-protective levels of choline were fed, the addition of vitamin 12 caused a significant increase in weight gain.”

“METHYL donors such as betaine and choline are known to stimulate production of vitamin B12 by certain microorganisms1.”

“Cystine exerts a positive … is low in and vitamin B12 and … choline and methionine.16 Some evidence suggests that unidentified factors may be present in the protein molecule which affect liver …, has recently been purified from casein and from certain yeasts which protects rats against dietary necrotic liver degeneration.’?.”