Possible Interaction: Choline and Thiamine

“The effect is ascribed by the writers to the circumstance that aneurin promotes the acetylization of choline , thus rendering the synaptic reaction more sensitive.”

“Basic drugs such as eperisone, thiamine and scopolamine significantly inhibited choline uptake by the BBB with the half inhibitory concentration, IC50 value of 1.45, 2.06, and 0.47 mM, respectively.”

“The uptake of choline by the isolated bovine brain capillaries was significantly inhibited by eperisone, scopolamine and thiamine in consistent with the in vivo results.”

“Analogues of choline such as hemicholinium‐3, thiamine , ethanolamine and N,N‐dimethylethanolamine inhibited choline unidirectional influx, whereas betaine and acetate had no effect.”

“Although a Lineweaver-Burk plot of choline uptake in the presence of thiamine showed that thiamine also competitively inhibited choline uptake, a Dixon plot of the inhibition experiment was hyperbolic and indicated that the inhibition of choline uptake by thiamine was 'pseudo-competitive'.”

“Quaternary ammonium compounds, such as choline and acetylcholine significantly inhibited thiamine uptake in isolated rat hepatocytes.”

“ Thiamine , pyrithiamine, oxythiamine, chloroethylthiamine and dimethialium inhibited choline uptake, while thiamine phosphates such as thiamine monophosphate and thiamine pyrophosphate insignificantly inhibited uptake.”

“Among quarternary ammonium compounds other than thiamine derivatives, choline and acetylcholine significantly inhibited thiamine uptake by rat liver cells, whereas betaine and carnitine did not.”

“Although the transports of choline and thiamine are mutually antagonistic, results of a kinetic test indicate that there probably is not a single common site for choline and thiamine absorption.”

“ Choline and high concentrations of Cu and Zn significantly increased VA, VK3, VB1 , and VB2 loss during storage (p<0.05).”

“IN a previous communication [McHenry, 1935] results have been described showing that choline and vitamin B1 have a complementary effect in increasing the weights of young rats.”

“The presence of choline in the diet decreases liver fat and masks the opposite effect shown by vitamin B1.”