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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Choline
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“Both the induction and maintenance of epileptiform activity was blocked by inhibiting action potential generation with tetrodotoxin or substitution of sodium with choline or by blocking AMPA/KA ionotropic glutamate receptors.”
Activity-dependent induction and maintenance of epileptiform activity produced by group I metabotropic glutamate receptors in the rat hippocampal slice“Depolarization above ‐40 mV activated a fast transient sodium inward current that was eliminated by substituting Na+ for choline and blocked in the presence of 1 μM TTX.”
“The inward current was transient, eliminated by substitution of choline for Na+ in the bathing solution, and reduced by 50% in the presence of 1 μM tetrodotoxin.”
“Addition of tetrodotoxin or replacement of the Cl- ions by OAc- ions or of the Na+ ions by choline ions reduced the depolarizing afterpotential and the action potential.”
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