Possible Interaction: Choline and Tetraethylammonium

“For osmotic gradients larger than 23 mosmol l-1 the volume change recorded with Ch+ was smaller than that recorded with TMA+ as volume marker.”

“ Choline and 2,4-dinitrophenol significantly inhibited the nasal absorption of tetraethylammonium.”

“ TEA+ may compete with choline at an intracellular site involved in the maintenance of releaseable ACh.”

“Summary The competitive inhibition by choline of tetraethylammonium uptake in mouse kidney slices suggests that these monoquaternary amines share a common transport mechanism.”

“Abstract The mechanism was studied of the inhibition of entry of choline ( N -… fibre by some quaternary ammonium compounds, Hemicholinium ( K i = 0·16 mM), tetraethylammonium ( K i = 56 mM), tetramethylammonium ( K i = 10 mM), … decamethonium K i = 3·7 mM) competitively inhibited choline entry , whereas hexamethonium … inhibitory effect.”

“Tetramethylammonium and tetraethylammonium ions were shown to be competitive inhibitors of the facilitated choline uptake.”