Possible Interaction: Choline and Scopolamine

“of oral choline given in a single dose were found to partially reverse the amnestic and subjective effects of 0.43 mg of scopolamine.”

“Pretreatment with choline caused a small but significant decrease in this impairment and partially reversed the mood changes produced by scopolamine.”

“The EC 50 for the inhibitory action was 300 μM. Scopolamine (10 nM) antagonized the effect of choline which indicates that the inhibition of 3H-acetylcholine outflow is mediated by muscarine receptors.”

“Basic drugs such as eperisone, thiamine and scopolamine significantly inhibited choline uptake by the BBB with the half inhibitory concentration, IC50 value of 1.45, 2.06, and 0.47 mM, respectively.”

“The uptake of choline by the isolated bovine brain capillaries was significantly inhibited by eperisone, scopolamine and thiamine in consistent with the in vivo results.”

“By contrast, scopolamine decreased the choline level in the extracellular fluid about 2-fold in both brain regions, possibly owing to enhanced choline uptake into the presynaptic nerve terminals.”

“ Scopolamine also increased spontaneous motor activity over the same time course as the changes in ACh and choline.”

“14-Day treatment with scopolamine (0.5 mg/kg/d) elicited an increase of the extraction and the PS-product (permeability-surface area) of choline which was prevented by coinjection of piracetam or pramiracetam (100 mg/kg/d).”

“The uptake of 1 microM Ch at 37 degrees C was inhibited by 1 mM scopolamine and was reduced in a dose-dependent manner by the irreversible anticholinesterase diisopropylfluorophosphate (DFP).”

“A similar potentiating … was described for choline by Bell (1967), but which differed from the present experiments in being blocked by hyoscine ; the action of TEC and TEA did not appear to be at muscarinic or nicotinic ganglionic sites since neither atropine (5 x g/ml) altered the potentiation.”