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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Concentrations of cystathionine, cysteine, betaine, choline , dimethylglycine, S-adenosylhomocysteine (SAH), S-adenosylmethionine ( SAM ), and holotranscobalamin were significantly higher in DS compared to the controls.”
Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.“ Choline intake affected the change in plasma S-adenosylmethionine (P = 0.044), with decreases tending to be greater (P < or = 0.08) in the 300 and 550 mg/d groups than in the 2200 mg/d group.”
“Supplementation with lecithin or choline also increased plasma methionine and SAM.”
“ Choline , via betaine, provides methyl groups for the production of S-adenosylmethionine , a substrate of DNA methyltransferases (DNMTs).”
Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression*“ Hepatic S-adenosylmethionine (AdoMet) concentrations are decreased in animals ingesting diets deficient in choline , and it has been suggested that this occurs because the availability of methionine limits AdoMet synthesis.”
“It is reported that SAMe accelerates synthesis of phosphatidyl choline and increases erythrocyte membrane fluidity.”
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