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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Choline
drug:
Quinacrine
Research Papers that Mention the Interaction
“Inhibitors of phospholipase activity such as mepacrine , zinc or cadmium ions significantly reduce this increased release of choline from poliovirus-infected cells.”
Enhancement of phospholipase activity during poliovirus infection.“Resting efflux of choline was reduced by mepacrine , a phospholipase A2 inhibitor, by perfusion with a Ca2+-free Tyrode's solution containing EGTA and by the combination mepacrine plus Ca2+-free/EGTA solution.”
Characterization of choline efflux from the perfused heart at rest and after muscarine receptor activation“However, the mobilization of choline was completely depressed by lowering extracellular calcium and by 0.1 mM mepacrine.”
“Both infusion of a Ca2(+)-free EGTA-containing Tyrode solution and mepacrine reduced the spontaneous efflux of choline by about 40% and blocked the PDB-evoked efflux of choline.”
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