Possible Interaction: Choline and Physostigmine

“Decompensation can be produced by large doses of penicillin G, physostigmine , or diisopropyl fluorophosphate, agents known to be inhibitory in the choline cycle.”

“ Physostigmine , an anti-cholinesterase lacking …, decreased the uptake of Ch to 73% of control at 1 mM. The rat iris is a much more homogeneous and readily accessible tissue than … CNS, therefore, it offers several advantages in pharmacological studies of drug action on a selective population of cholinergic terminals.”

“The hypotensive response to choline was enhanced by prior administration of physostigmine into the medullary site, while hemicholinium-3, similarly administered, abolished the response.”

“We have found that when … of brain ACh and Ch is increased to a new steady … a result of oxotremorine and physostigmine injections the turnover rate of brain ACh decreases from 0.34 mumol/g/hr (… saline-treated mice) to 0.12 and 0.061 mumol/g/hr, respectively.”

“Administration of pentobarbital, chloral hydrate, morphine, physostigmine , Δ9 THC, hemicholinium-3 and oxotremorine, drugs which decrease ACh turnover and release, caused a reduction in choline uptake.”

“The cholinesterase inhibitor (ChEI) physostigmine inhibited ACh and Ch uptake, while the two ChEI:s soman and sarin stimulated the uptake of both ACh and Ch.”

“Oxotremorine, 0.7 mg/kg, and physostigmine , 0.5 mg/kg, increased choline levels in mouse whole brain and cerebellum.”

“ Physostigmine , 0.5 mg/kg, oxotremorine, 2 mg/kg free base, and haloperidol, 4 and 8 mg/kg, increased both acetylcholine and choline 20 min after administration.”

“d-Tubocurarine was an inhibitor of choline uptake, and physostigmine , a tertiary compound, also inhibited choline uptake.”