Possible Interaction: Choline and Phosphatidylethanolamine

“The significance of choline in the regulation of phosphatidylethanolamine synthesis is discussed.”

“Ethanolamine inhibited PC synthesis and choline inhibited PE synthesis.”

“Analysis of egg samples at peak production (36 wk of age) showed significant (P less than .05) elevations in total phospholipids, phosphatidylcholine (PC), and the ratio of PC to phosphatidylethanolamine PE ), when choline was added at 500 or 1,000 ppm.”

“Hence, choline may provide an additional mechanism for the regulation of phosphatidylethanolamine biosynthesis.”

“Incorporation of label into phosphatidylethanolamine was decreased 28% at 0.2-0.5 mM choline.”

“b) The choline analogues also affected the acyl chain composition of the other membrane phospholipid species, e.g. phosphatidylcholine, phosphatidylethanolamine , phosphatidylserine, phosphatidylinositol, and cardiolipin.”

“Further analysis indicated that the number of double bonds of phosphatidyl choline and the content of carbon atoms of phosphatidyl ethanolamines were negatively associated with death risk.”

“The nitrogen moieties, ethanolamine and choline influenced the induction period for the oxidation of PE and PC respectively.”

“In agreement with previous observations, uptake of exogenous choline down-regulates the methylation of phosphoethanolamine , without being accompanied by secondary accumulation of a marked excess of ethanolamine derivatives.”

“… choline are almost equally … group of phosphatidylmonomethylethanolamine and as a result the half-life of the latter is between 27 and 37 h. These observations, viewed in the … that internal recycling of the polar head group may be a vital process of maintaining cellular phospholipids under steady-state conditions.”