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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Choline and Phenobarbital



Research Papers that Mention the Interaction

The ability of the dietary methyl donors methionine and choline to inhibit the carcinogenic and tumor-promoting effects of phenobarbital (PB) in the livers of male weanling C3H mice was examined.
Carcinogenesis  •  1990  |  View Paper
It was found that phenobarbital , barbital and muscimol injected into the medial septal area inhibited choline uptake in the hippocampus.
The inhibition of choline uptake by phenobarbital was blocked by coadministration of picrotoxin in the medial septum.
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper
Administration of phenobarbital to female rats significantly increased the levels of liver monoenoic, dienoic and tetraenoic PC and in plasma it raised phosphatidyl choline and its monoenoic and dienoic species and decreased triglyceride levels.
Biochemistry and experimental biology  •  1980  |  View Paper
Experiments measuring hepatic choline uptake in the isolated perfused liver have demonstrated that phenobarbital inhibits this mechanism by 50 %.
Pharmacology  •  1974  |  View Paper