supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Choline
drug:
Phenobarbital
Research Papers that Mention the Interaction
“The ability of the dietary methyl donors methionine and choline to inhibit the carcinogenic and tumor-promoting effects of phenobarbital (PB) in the livers of male weanling C3H mice was examined.”
The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital.“It was found that phenobarbital , barbital and muscimol injected into the medial septal area inhibited choline uptake in the hippocampus.”
“The inhibition of choline uptake by phenobarbital was blocked by coadministration of picrotoxin in the medial septum.”
“Administration of phenobarbital to female rats significantly increased the levels of liver monoenoic, dienoic and tetraenoic PC and in plasma it raised phosphatidyl choline and its monoenoic and dienoic species and decreased triglyceride levels.”
“Experiments measuring hepatic choline uptake in the isolated perfused liver have demonstrated that phenobarbital inhibits this mechanism by 50 %.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback