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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
drug:
Phencyclidine
Research Papers that Mention the Interaction
“ Choline and MEC stimulated the binding of [3H]phencyclidine to the nicotinic ion channel (EC50's = 79 and 115 microM, respectively).”
Precursors of cholinergic false transmitters: Central effects on blood pressure and direct interactions with cholinergic receptors“In contrast to atropine (40.0 mg/kg), which increased the uptake … in synaptosomes from both the rat hippocampus and striatum, the administration of phencyclidine (54.4 mg/kg), 30 min prior to …, caused a significant decrease in the uptake of choline in synaptosomes from rat … (but not hippocampus).”
“The data suggest that phencyclidine may be exerting an indirect effect on the uptake of choline in the striatum via its interaction with the dopaminergic system.”
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