Possible Interaction: Choline and Pentobarbital

“On the contrary, the D2 agonist (±)‐2‐(N‐phenylethyl‐N‐propyl)amino‐5‐hydroxytetralin (N‐434; 5 mg/kg) and an anesthetic, pentobarbital (50 mg/kg), decreased ACh levels and increased Ch levels.”

“ Choline supplementation attenuated both the sedative/hypnotic and hypothermic effects of pentobarbital through an action that could not be attributed to either an enhanced peripheral metabolism of pentobarbital or to an attenuation of the cholinergic effects of pentobarbital.”

“Rather, results indicate that chronic supplementation with choline increases cerebral glucose metabolism and causes a behavioral hyperactivity, effects that may mediate the attenuation of the behavioral response of pentobarbital.”

“At 7 min after injection, levels of pentobarbital in the hippocampus (and other brain regions) were correlated with the degree of inhibition of choline uptake up to about 50% inhibition; however, greater inhibition could not be achieved with much higher brain levels of the drug.”

“ Pentobarbital (pb) administered in vivo results in an inhibition of high affinity choline uptake measured in hippocampal synaptosomes in vitro.”

“Administration of pentobarbital , chloral hydrate, morphine, physostigmine, Δ9 THC, hemicholinium-3 and oxotremorine, drugs which decrease ACh turnover and release, caused a reduction in choline uptake.”