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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Uptake of labelled choline was partially inhibited by nicotine , strongly inhibited by hemicolinium-3, and was reduced by about 50 per cent in sodium-free perfusates.”
Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells.“At concentrations of 10-2 to 10-3, choline blocked totally or almost totally the axon reflex sweat responses to nicotine in 10-5 and to acetylcholine 10-4, possibly by acting on the receptors for the sweating axon reflex.3.”
“Two key chromatin remodeling genes, Smarca2 and Bahcc1, exhibited inversely correlated changes in methylation and expression due to nicotine exposure; this was reversed by choline.”
Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure“In conclusion long-term nicotine treatment may selectively increase GLU and ASP overflow elicited by KCl, 4AP and Ch through the activation of a carrier-mediated release mechanism and completely abolished the stimulatory effects of α4β2 nAChRs which modulate the release of all the three AA.”
“In contrast, the CHO + NIC prenatal treatment produced a dramatic increase in timing precision and selective control of the resetting mechanism with no change in overall timing accuracy.”
“The synergistic effect of combining prenatal CHO and NIC treatments suggests an organizational change in alpha7 nAChR function that is dependent upon a combination of selective and nonselective nAChR stimulation during early development.”
“When given in combination with nicotine, choline protected some regions from damage but worsened nicotine's effects in other regions.”
“ Choline also exhibited only about 40% of the full cytoprotective effect of nicotine.”
“Continuous exposure for 10-15 min of the neurons to nicotine (0.5-2.5 microM) inhibited alpha7 nAChR-mediated currents (IC(50)=640 nM) evoked by choline (10 mM).”
“Replacement of external Na by choline completely abolished the contractile responses evoked by nicotine and EFS.”
“When a tracer dose of labelled choline (3H-Ch) was given to mice treated with nicotine (4 mg/kg) a marked increase (+100%) in the biosynthesis of labelled acetylcholine (ACh) in the striatum was found when the animals were killed by decapitation.”
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