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Last Updated: 2 years ago

Possible Interaction: Choline and Nicotine

supplement:

Choline

Research Papers that Mention the Interaction

Uptake of labelled choline was partially inhibited by nicotine , strongly inhibited by hemicolinium-3, and was reduced by about 50 per cent in sodium-free perfusates.
Placenta  •  1998  |  View Paper
At concentrations of 10-2 to 10-3, choline blocked totally or almost totally the axon reflex sweat responses to nicotine in 10-5 and to acetylcholine 10-4, possibly by acting on the receptors for the sweating axon reflex.3.
Archives internationales de physiologie et de biochimie  •  1959  |  View Paper
Two key chromatin remodeling genes, Smarca2 and Bahcc1, exhibited inversely correlated changes in methylation and expression due to nicotine exposure; this was reversed by choline.
Neurobiology of Learning and Memory  •  2018  |  View Paper
In conclusion long-term nicotine treatment may selectively increase GLU and ASP overflow elicited by KCl, 4AP and Ch through the activation of a carrier-mediated release mechanism and completely abolished the stimulatory effects of α4β2 nAChRs which modulate the release of all the three AA.
Neurochemistry International  •  2012  |  View Paper
In contrast, the CHO + NIC prenatal treatment produced a dramatic increase in timing precision and selective control of the resetting mechanism with no change in overall timing accuracy.
The synergistic effect of combining prenatal CHO and NIC treatments suggests an organizational change in alpha7 nAChR function that is dependent upon a combination of selective and nonselective nAChR stimulation during early development.
Learning & memory  •  2006  |  View Paper
When given in combination with nicotine, choline protected some regions from damage but worsened nicotine's effects in other regions.
Neuropsychopharmacology  •  2005  |  View Paper
Choline also exhibited only about 40% of the full cytoprotective effect of nicotine.
Synapse  •  2003  |  View Paper
Continuous exposure for 10-15 min of the neurons to nicotine (0.5-2.5 microM) inhibited alpha7 nAChR-mediated currents (IC(50)=640 nM) evoked by choline (10 mM).
Neuropharmacology  •  2000  |  View Paper
Replacement of external Na by choline completely abolished the contractile responses evoked by nicotine and EFS.
General pharmacology  •  1995  |  View Paper
When a tracer dose of labelled choline (3H-Ch) was given to mice treated with nicotine (4 mg/kg) a marked increase (+100%) in the biosynthesis of labelled acetylcholine (ACh) in the striatum was found when the animals were killed by decapitation.
Acta pharmacologica et toxicologica  •  1983  |  View Paper
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