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Last Updated: 3 years ago

Possible Interaction: Choline and Niacin





Research Papers that Mention the Interaction

Nicotinamide supplementation increased the plasma levels of nicotinamide, N1-methylnicotinamide and choline and decreased the levels of betaine, which is associated with a decrease in global hepatic DNA methylation and uracil content in DNA.
British Journal of Nutrition  •  2013  |  View Paper
Furthermore, we found that α7 nicotinic , muscarinic, and opioid-receptors are involved in the antinociceptive effect of choline in the writhing test and the antinociceptive effect produced by systemically administered choline may be via a peripheral mechanism.
European journal of pain  •  2011  |  View Paper
Central choline also activates the sympatho-adrenal system by increasing central nicotinic cholinergic neurotransmission.
Autonomic & autacoid pharmacology  •  2008  |  View Paper
Concomitantly, nicotinamide caused increases of the choline levels in the venous brain blood.
We conclude that nicotinamide enhances brain choline concentrations by mobilising choline from choline-containing phospholipids, presumably via activation of phospholipase A2, while the formation of NMN does not contribute to this effect.
Neuroscience Letters  •  1998  |  View Paper
High-choline diet, hypoxia and treatment with nicotinamide increased brain choline availability through a central site of action and increased the CSF choline concentration.
Neurochemistry International  •  1998  |  View Paper
The combined administration of choline and nicotinamide had a synergistic effect on brain choline levels but had similar effects as nicotinamide given alone in the behavioral experiments.
Pharmacology Biochemistry and Behavior  •  1996  |  View Paper
The combined administration of choline and of a choline transport blocker analogous to nicotinamide may be of potential use in central cholinergic dysfunction.
injection of 5 and 10 mmol/kg of nicotinamide caused increases of extracellular choline by 54 and 113%, respectively, and choline levels remained elevated for several hr.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper