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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Choline and Neuromuscular Depolarizing Agents

Research Papers that Mention the Interaction

Choline potentiates the depolarizing effect of acetylcholine (Ach) when applied in normal Ringer.
Proceedings of the Royal Society of London. Series B - Biological Sciences  •  1957  |  View Paper
Moreover, Ch uptake is stimulated by prior incubation under depolarizing conditions relative to normal preincubation when the second incubation is in a high K+ solution.
We have confirmed the observation that a prior depolarizing incubation results in an enhanced uptake of Ch during a second incubation in normal K+ Krebs.
Journal of neurochemistry  •  1981  |  View Paper
Substitution with choline had no effect but choline may permeate through the membrane during the depolarizing response.
Brain Research  •  1981  |  View Paper