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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
drug:
Nerve Growth Factor
Research Papers that Mention the Interaction
“Furthermore, NGF is able to prevent the degeneration of cholineric neurons in adult rats with experimental lesions mimicking the cholinergic deficit in Alzheimer's disease.”
Nerve growth factor and Alzheimer's disease“ Choline supplementation increased striatal ChAT activity and also enhanced NGF and BDNF expression in cortical and hippocampal regions.”
Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation“ Choline supplementation increased striatal nerve growth factor expression in wild-type and Mecp2(1lox) mice, suggesting that neuronal proliferation and survival may contribute to improved motor performance in this model of RTT.”
“The results showed that application of NGF on the eye surface protected choline acetyl transferase levels.”
“This further suggests that intracellular pools of choline , which do not normally serve as substrate for ACh synthesis, may be made available for ACh synthesis in the presence of NGF.”
“However, nerve growth factor , but not monosialoganglioside GM1 treatment also increased choline acetyltransferase-immunoreactive varicosity number above control levels.”
“By contrast, the concentration of Chol‐1 expressed either per unit weight of ganglioside sialic acid or protein increased considerably in culture and this increase was enhanced by NGF.”
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