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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The reduction in withdrawal severity by treatment with choline during the habituation to morphine indicates an inhibition of the development of dependence rather than mere suppression of the signs during withdrawal.”
Effects of cholinergic and anticholinergic drugs and a partial cholinergic agonist on the development and expression of physical dependence on morphine in rat.“Similarly, coadministration of choline (2 mg/kg) with morphine (0.165 mg/kg) significantly increased the antinociception of morphine in the late phase, but had no effect in the early phase.”
Antinociceptive effects of choline against acute and inflammatory pain“It was also shown that under morphine physical dependence the acyl residues of phosphatidyl choline and phosphatidyl ethanolamine changed.”
“Pretreatment with Ch (100 mg/kg, IP; given 20 min earlier) reduced morphine and soman analgesia by 68% and 38% respectively.”
“Acute administration of analgesic doses of morphine (10 mg/kg, 20 mg/kg) significantly stimulated choline uptake into synaptosomes in a naloxone-reversible manner.”
“The mortality to a combined fixed dose of morphine and choline was reduced by naloxone but not by physostigmine and atropine.”
“The studies revealed that the toxic interaction between morphine and choline treatment was time dependent and that the LD50 of each compound was markedly decreased by the coadministration of increasing doses of the other compound.”
“Administration of pentobarbital, chloral hydrate, morphine , physostigmine, Δ9 THC, hemicholinium-3 and oxotremorine, drugs which decrease ACh turnover and release, caused a reduction in choline uptake.”
“Cocaine (particularly in adrenalectomized cats), morphine and methadone considerably reduced or blocked the ganglionic effect of choline.”
“ Morphine and methadone in vitro inhibited the Na+-dependent choline uptake.”
Isotopic labeling of synaptosomes that accumulate choline and the effect of narcotic drugs
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