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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Choline
drug:
Miltefosine
Research Papers that Mention the Interaction
“Finally, we have demonstrated using inhibition studies with choline analogs that miltefosine and octadecyltrimethylammonium bromide are potent inhibitors of this metabolic pathway.”
“ Miltefosine has structural similarity to the PC and sphingomyelin substrates of PlcHR, and we found that it inhibits the cleavage of these choline-containing lipids in vitro.”
Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection.“ HexPC inhibited the incorporation of choline into phosphatidylcholine and the pattern of accumulation of soluble choline-derived metabolites pinpointed CTP:phosphocholine cytidylyltransferase (CT) as the inhibited step in vivo.”
“ HePC substantially inhibited the membrane uptake of inositol and of choline in KB and Raji.”
“In further experiments, we demonstrated that HePC inhibited the incorporation of radiolabeled choline into phosphatidylcholine and at a later time point into sphingomyelin.”
Induction of Ceramide-mediated Apoptosis by the Anticancer Phospholipid Analog, Hexadecylphosphocholine*
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