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Possible Interaction: Choline and Methotrexate

supplement:

Choline

Research Papers that Mention the Interaction

MTX increased the extent of fatty infiltration of the liver in choline deficient rats, and choline deficiency and MTX treatment damaged hepatocytes as measured by leakage of alanine aminotransferase activity.
The Journal of nutritional biochemistry  •  1990  |  View Paper
In addition, MTX also decreases levels of AdoMet5,6, choline and betaine6 in various rat tissues, and causes an increase in urinary wasting of endogenous folates in the rat kidney7.
Advances in experimental medicine and biology  •  1993  |  View Paper
Because choline has a lipotropic effect and because its synthesis requires methylation, an attempt was made to block the liver toxicity of methotrexate by simultaneous administration of choline.
Furthermore, the accumulation of triglycerides in the liver which was characteristic of methotrexate administration was markedly reduced in those animals receiving choline.
Medical and pediatric oncology  •  1977  |  View Paper
They also show that methionine and choline , products of 1-carbon metabolism beyond folate involvement, overcame the detrimental effects of MTX.
This suggests that MTX interferes with hepatic methyl group genesis and hence blocks the de novo synthesis of methionine and choline.
Biochemical pharmacology  •  1975  |  View Paper