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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
drug:
Methotrexate
Research Papers that Mention the Interaction
“In addition, MTX also decreases levels of AdoMet5,6, choline and betaine6 in various rat tissues, and causes an increase in urinary wasting of endogenous folates in the rat kidney7.”
MTX does not affect enhanced biosynthesis and metabolism of S-adenosylmethionine in testosterone-induced hypertrophic mouse kidney.“Because choline has a lipotropic effect and because its synthesis requires methylation, an attempt was made to block the liver toxicity of methotrexate by simultaneous administration of choline.”
“They also show that methionine and choline , products of 1-carbon metabolism beyond folate involvement, overcame the detrimental effects of MTX.”
“This suggests that MTX interferes with hepatic methyl group genesis and hence blocks the de novo synthesis of methionine and choline.”
“ MTX increased the extent of fatty infiltration of the liver in choline deficient rats, and choline deficiency and MTX treatment damaged hepatocytes as measured by leakage of alanine aminotransferase activity.”
Effects of choline deficiency and methotrexate treatment upon rat liver.
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