Possible Interaction: Choline and Methionine

“Even in healthy subjects intake of choline together with methionine is insufficient to satisfy total metabolic requirements for methyl groups.”

“The inverse associations of methionine and total methyl donors including choline , betaine and methionine with pancreatic cancer risk in both cohorts support that DNA repair and methylation play an important role against the development of pancreatic cancer.”

“Supplementation with lecithin or choline also increased plasma methionine and SAM.”

“Our data clearly demonstrates the highly inter-related dependence of methyl donors choline , betaine, SAM) and the methionine cycle for maintenance of thiol homeostasis.”

“Our results suggest that Pb(2+) induces ER calcium release to increase the resting [Ca(2+)](i); and methionine choline inhibit this increase in [Ca(2+)](i).”

“The present results suggest that the coupling of high levels of choline and low levels of methionine plays an important role in the development of insulin resistance and liver steatosis.”

“ Methionine increased both the amount of phosphatidyl choline and its content of arachidonic acid.”

“The addition of choline or carnitine to the choline-deficient diet did not induce a gain in body weight, while the addition of either betaine or methionine to the choline-deficient diet, or of methionine to the choline-deficient diet with choline significantly increased the body weight.”

“Dietary methionine significantly affected weight gain and FE, whereas dietary choline significantly affected weight gain, FE and survival, and the interaction of methionine and choline significantly affected weight gain.”

“Growth of quail fed purified … up to 1.35% excess methionine which were limiting (… mg/kg) in choline was less than that of groups fed 2000 mg/kg of added dietary choline (P less … .01); however, excess methionine did not significantly influence growth of quail fed choline-deficient diets.”