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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In vitro, metformin significantly decreased the bacterial production rate of trimethylamine (TMA), the precursor of TMAO, from choline up to 3.25-fold in K. pneumoniae and up to 26-fold in P. Mirabilis, while significantly slowing the growth of P. Mirabilis only.”
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice“The results suggested that metformin suppresses serum TMAO level by remodeling gut microbiota involved in TMA generation from choline.”
Metformin alleviates choline diet-induced TMAO elevation in C57BL/6J mice by influencing gut-microbiota composition and functionality
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