Possible Interaction: Choline and Mechlorethamine

“Cytotoxicity induced by HN2 was also prevented by choline , suggesting that a choline carrier is responsible for HN2 uptake in the hepatocytes.”

“Exposure of cells to choline prior to HN2 treatment was no more effective than administration of choline simultaneously with drug therapy.”

“The D o (the dose of drug reducing survival …% of the initial cell population) for cells treated with HN2 was increased 6.5-fold … presence of 1 mm choline and 12.7-fold in the presence of 1 mm … each of these observations was highly significant ( p < 0.001).”

“ECMA at concentrations of 50 μM hardly affected choline acetyltransferase and … of choline kinase at a concentration of 1 mM. However, the mustard was an extremely effective inhibitor of choline dehydrogenase, producing 50% inhibition …. The inhibition was prevented by incubation in the presence of choline or by … with thiosulphate.”