Possible Interaction: Choline and Mecamylamine

“Blood pressure responses to choline (150 µg) were attenuated by pretreatment with both mecamylamine and atropine.”

“In cultured superior cervical … and rat, choline (0.1-30 mM)-evoked … by 1-30 microM mecamylamine , 1-30 microM methyllycaconitine, 10-300 nM alpha-bungarotoxin, and 0.1-10 microM desipramine and … the presence of similar functional alpha7-nAChRs in cerebral perivascular sympathetic neurons of pigs and rats.”

“The LTPn induced by epibatidine at 3.0 mug/kg or choline at 30 mg/kg was significantly suppressed by pre-treatment but not post-treatment with mecamylamine (0.5 mg/kg, i.p.),”

“ choline (150 microg) was inhibited by pretreatment with the nicotinic receptor antagonist, mecamylamine (50 microg; i.c.v.),”

“The rat's exploratory behaviour tended to be attenuated by central administration of hemicholinium (a choline uptake blocker), and it was significantly inhibited by mecamylamine (a nicotinic receptor antagonist), and pirenzepine (a selective M1 receptor antagonist).”

“blocked the hypothermic effect of choline (150 microg), but the response was only partially attenuated by pre-treatment with the nicotinic receptor antagonist, mecamylamine (20 microg, i.c.v.).”

“ Mecamylamine abolished vasopressin response to endotoxin as well as to choline.”

“Pretreatment of rats with mecamylamine (50 micrograms; intracerebroventricularly), the nicotinic receptor antagonist, completely inhibited the ACTH and beta-endorphin response to choline (150 micrograms; intracerebroventricularly).”