Possible Interaction: Choline and Lidocaine

“At 3·2 mM lidocaine , the reduction of choline uptake was shown to follow a competitive inhibition.”

“ Lidocaine inhibited the … of choline uptake in a dose‐dependent manner; at 3·2 mM it resulted in a drastic reduction, by as much as 65 per … (n = 10; p < 0·0005) or 55 per cent (n = 10; p < 0·0006) in a 3‐ or 6‐h incubation, respectively.”

“Taken together, we have demonstrated a dual inhibitory function of lidocaine which inhibits PC biosynthesis in addition to its ability to block choline uptake profoundly in U937 cells.”