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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
drug:
Isoflurophate
Research Papers that Mention the Interaction
“Decompensation can be produced by large doses of penicillin G, physostigmine, or diisopropyl fluorophosphate , agents known to be inhibitory in the choline cycle.”
The relation of the choline cycle to cardiac decompensation; acetylcholine metabolism in the dog heart-lung preparation.“Twenty-four hours after the last injection of DFP, only a higher dose of DFP (2 mg/kg) significantly inhibited choline uptake.”
Evidence for the involvement of presynaptic cholinergic functions in tolerance to diisopropylfluorophosphate.“ DFP administration to rats (6 mg/kg) also lowered the in vitro release of choline by 33%.”
“Perfusion of the isolated hemidiaphragm with 10 microM or 100 microM DFP reduced choline efflux by 39% and 69% respectively.”
“These results demonstrate that DFP inhibits choline efflux from the isolated hemidiaphragm and further suggest that, by limiting the availability of choline for ACh synthesis, DFP reduces the rate of ACh release.”
“Levels of choline Ch ) in the iris were decreased by 22% 5 min after the application of DFP but quickly returned to normal and were the same as controls at all other times tested.”
“ Choline levels then became significantly greater than control values after 10 and 22 days of chronic treatment with DFP.”
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