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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Choline
drug:
Imipramine
Research Papers that Mention the Interaction
“Several commonly prescribed pharmaceuticals known to cross the placental barrier including imipramine , verapamil, propranolol, quinine, flurazepam, amiloride and ritodrin were observed to inhibit conductive choline uptake suggesting an interaction with the mechanism mediating conductive choline transport.”
Choline transport in human placental brush-border membrane vesicles.“In slices of the granular layer also a slight Na+-dependence was observed for both serotonin and choline uptake; imipramine and hemicholinium partially inhibited the uptake of serotonin and choline , respectively.”
Neurotransmitters of the cerebellar glomeruli: uptake and release of labeled γ-aminobutyric acid, glycine, serotonin and choline in a purified glomerulus fraction and in granular layer slices“ Imipramine and thioridazine (moderately potent anticholinergics) increased the uptake of choline only in the striatum.”
“The high-affinity uptake of choline by rat cerebral cortical slices was inhibited by high concentrations (10-100 microM) of the tricyclic antidepressant drugs imipramine , desipramine, and iprindole in vitro.”
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