Possible Interaction: Choline and Homocysteine

“ Choline or betaine supplementation in … reduces concentration of total homocysteine (tHcy), and plasma betaine is a strong predictor of plasma tHcy in individuals with low plasma concentration of folate and other B vitamins (B2, B6, and B12) in combination TT genotype of the methylenetetrahydrofolate reductase 677 C->T polymorphism.”

“We hypothesized that choline supplementation would result in lower plasma homocysteine concentrations in children with CF.”

“ Choline supplementation induced a median (25th, 75th percentile) change in plasma tHcy concentration at week 6 of − 0·9 ( − 1·6, 0·2) μmol, a change which, when compared to that observed in the placebo group 0·6 ( − 0·4, 1·9) μmol, approached statistical significance (P = 0·058).”

“Intakes of choline and betaine, as methyl donors, may affect homocysteine concentrations.”

“CONCLUSIONS Dietary betaine and supplementary betaine acutely increase plasma betaine, and they and ch line at tenuate the postmethionine load rise in hom ocysteine concentrations. ”

“BACKGROUND Choline and betaine are found in a variety of plant and animal foods and were recently shown to be associated with decreased homocysteine concentrations.”

“Except for choline from phosphatidylcholine, individual forms of choline were inversely associated with tHcy concentrations.”

“Deficiency of methyl donors (MDs, folate, vitamin B12, and choline ) causes increased plasma level of Hcy , a risk factor for cardiovascular diseases.”

“Plasma choline and phosphatidylcholine concentrations were not different across treatment groups, but maternal choline supplementation resulted in a significant reduction in homocysteine concentrations in LP + C offspring compared with LP and CONT animals.”

“N-acetyl-L-cysteine and choline ameliorated global DNA hypomethylation induced by HCY.”