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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Choline
drug:
Hiperforina
Research Papers that Mention the Interaction
“In rat hippocampal slices, hyperforin inhibited the NMDA-receptor-mediated release of choline from phospholipids.”
NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.“In rat brain synaptosomes, hyperforin inhibited high-affinity choline uptake with an IC(50) of 8.5 microM, whereas low-affinity uptake was not affected.”
“Infusion of a lower concentration of hyperforin (10 microM), however, increased striatal ACh release and lowered Ch levels.”
“Local infusion of hyperforin (100 microM) via the dialysis probe caused a delayed reduction of ACh release and a concomitant increase of Ch levels.”
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