supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Choline
drug:
Hiperforina
Research Papers that Mention the Interaction
“In rat hippocampal slices, hyperforin inhibited the NMDA-receptor-mediated release of choline from phospholipids.”
NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.“In rat brain synaptosomes, hyperforin inhibited high-affinity choline uptake with an IC(50) of 8.5 microM, whereas low-affinity uptake was not affected.”
“Infusion of a lower concentration of hyperforin (10 microM), however, increased striatal ACh release and lowered Ch levels.”
“Local infusion of hyperforin (100 microM) via the dialysis probe caused a delayed reduction of ACh release and a concomitant increase of Ch levels.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback