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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Choline and Hexamethonium



Research Papers that Mention the Interaction

Pretreatment with atropine methyl nitrate failed to alter … responses to CDP-choline and its metabolites whereas hexamethonium , the ganglionic nicotinic receptor antagonist which blocks nicotinic cholinergic neurotransmission at the … level, blocked completely the hyperglycemia induced by CDP-choline, phosphocholine and choline , and attenuated the hyperglycemic … cytidine monophosphate and cytidine.
Archives of physiology and biochemistry  •  2007  |  View Paper
The increases in serum glucose and plasma catecholamine concentrations induced by choline (120 mg/kg) were blocked by pretreatment with the ganglionic nicotinic receptor antagonist hexamethonium (15 mg/kg), but were not affected by pretreatment with atropine (5 mg/kg).
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2002  |  View Paper
Secretion induced by a low concentration of choline was abolished by a nicotinic blocker, hexamethonium , while the response to choline at a concentration higher than 130 mM was only partially inhibited by cholinergic antagonists.
The Japanese journal of physiology  •  1982  |  View Paper
In 5 experiments, hexamethonium (20 peg), given intracisternally 5 min before the second administration of choline (50 i g), abolished the blood pressure responses to choline …
Japanese journal of pharmacology  •  1981  |  View Paper
The side effects of hexamethonium could be due primarily to this hemicholinium-like action, which can be antagonized by pretreatment of the animals with choline (6).
Journal of pharmaceutical sciences  •  1974  |  View Paper