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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Choline
drug:
Hexamethonium
Research Papers that Mention the Interaction
“Pretreatment with atropine methyl nitrate failed to alter … responses to CDP-choline and its metabolites whereas hexamethonium , the ganglionic nicotinic receptor antagonist which blocks nicotinic cholinergic neurotransmission at the … level, blocked completely the hyperglycemia induced by CDP-choline, phosphocholine and choline , and attenuated the hyperglycemic … cytidine monophosphate and cytidine.”
Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system“The increases in serum glucose and plasma catecholamine concentrations induced by choline (120 mg/kg) were blocked by pretreatment with the ganglionic nicotinic receptor antagonist hexamethonium (15 mg/kg), but were not affected by pretreatment with atropine (5 mg/kg).”
Intraperitoneal administration of choline increases serum glucose in rat: involvement of the sympathoadrenal system.“Secretion induced by a low concentration of choline was abolished by a nicotinic blocker, hexamethonium , while the response to choline at a concentration higher than 130 mM was only partially inhibited by cholinergic antagonists.”
“In 5 experiments, hexamethonium (20 peg), given intracisternally 5 min before the second administration of choline (50 i g), abolished the blood pressure responses to choline …”
“The side effects of hexamethonium could be due primarily to this hemicholinium-like action, which can be antagonized by pretreatment of the animals with choline (6).”
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