Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 24 days ago

Possible Interaction: Choline and Hemicholinium 3

supplement:

Choline

Research Papers that Mention the Interaction

Choline uptake was inhibited by the choline analogue hemicholinium-3 (HC-3) and various organic cations, and was significantly decreased by acidification of the extracellular medium.
Neurochemistry International  •  2011  |  View Paper
Choline uptake in the cells was inhibited by unlabeled choline and hemicholinium-3 as well as various organic cations including guanidine, amiloride and acetylcholine.
Placenta  •  2009  |  View Paper
HC-3 inhibited choline with a KI of 10.5± 2.2 μM. Ouabain (1 mM) caused a 94% reduction in choline uptake.
Molecular imaging  •  2006  |  View Paper
The hCHT-specific inhibitor hemicholinium-3 HC-3 ) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.
The Journal of Neuroscience  •  2006  |  View Paper
In support of the role of the choline kinase product phosphocholine … of mitogenic Ca2+ effects, cotreatments with the choline kinase substrate choline (250 microM) and … kinase inhibitor hemicholinium-3 (2 mM) enhanced and inhibited, respectively, the combined stimulatory effect … Ca2+ (3.8 mM total) and zinc on DNA synthesis.
European journal of biochemistry  •  1999  |  View Paper
Endogenous choline levels as determined by microwave fixation were 22.7 +/- 1.1 nmol g-1 and were unaffected by hemicholinium; however, hemicholinium caused a significant reduction in the postmortem increase in choline.
Psychopharmacology communications  •  1975  |  View Paper
Choline uptake was inhibited by choline, acetylcholine (ACh) and the choline analog hemicholinium-3 (HC-3).
Neurochemistry International  •  2016  |  View Paper
Five mm unlabelled choline, hemicolinium‐3 and guanidine, but not tetraethylammonium, inhibited the cellular uptake of 100 µm choline in LS180 cells.
Biopharmaceutics & drug disposition  •  2014  |  View Paper
HC-3 and CTL1 siRNA inhibited choline uptake and cell viability, and increased caspase-3/7 activity.
Various organic cations and the choline analog hemicholinium-3 (HC-3) inhibited the choline uptake and cell viability.
Pharmacological research  •  2013  |  View Paper
Choline uptake was inhibited by the choline analogue hemicholinium-3 (HC-3) and various organic cations, and was significantly decreased by acidification of the extracellular medium and by intracellular alkalinization.
Archives of biochemistry and biophysics  •  2009  |  View Paper
Show More