Possible Interaction: Choline and Guanidines

“ Choline uptake in the cells was inhibited by unlabeled choline and hemicholinium-3 as well as various organic cations including guanidine , amiloride and acetylcholine.”

“Five mm unlabelled choline, hemicolinium‐3 and guanidine , but not tetraethylammonium, inhibited the cellular uptake of 100 µm choline in LS180 cells.”

“Even though choline inhibited guanidine uptake it appeared to reverse this inhibition of virus replication primarily by blocking the intracellular action of guanidine.”

“The antiguanidine agents choline , dimethylethanolamine and tetraethylammonium, but not methionine, inhibited guanidine uptake by HeLa cells.”

“ Guanidine uptake was only minimally inhibited by organic cations such as tetraethylammonium, N1-methylnicotinamide, and choline , but many other organic cations such as amiloride, clonidine, imipramine, and harmaline caused considerable inhibition.”

“Abstract The ability of choline to block the inhibitory action of guanidine on poliovirus type 2 multiplication was studied in three cell types.”

“ Choline , dimethylethanolamine, and methionine all suppress the growth-supportin activity of 0.4 m M guanidine on a guanidine-dependent strain of poliovirus type 1.”

“Kinetic studies in all three cell types showed that 10 m M choline rapidly reversed the inhibitory effects of 0.4 m M guanidine.”

“However, certain low concentrations of choline and methionine were also able to partially prevent guanidine inactivation.”

“Abstract The inhibitory effect of guanidine on the multiplication of poliovirus in HeLa cells is suppressed by the amino acids methionine, leucine, and valine but also by choline.”