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Last Updated: 2 years ago

Possible Interaction: Choline and Gamma-Aminobutyric Acid

supplement:

Choline

Research Papers that Mention the Interaction

Our study provides evidence that choline can depress population-level activity, quite likely by facilitating the release of GABA from interneurons, and may thereby influence hippocampal function.
Nutritional neuroscience  •  2011  |  View Paper
Choline Chol ) but not N-methyl-D-glucamine (NMDG) substitution for sodium likewise increased GABA efflux.
Acta Neurochirurgica  •  2005  |  View Paper
Choline enhanced in a concentration-dependent way the release of endogenous GABA but did not affect that of the radioactive aminoacid.
Thus the release of endogenously synthesized GABA (but not that of the aminoacid taken up) may be regulated by Ch through a mechanism involving penetration into the releasing terminal through a Ch uptake system.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
When Na+ ions were replaced by choline , basal and K+-evoked GABA release was significantly increased.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Choline incorporation also inhibited GABA transport, although less than ethanolamine.
Neurochemical Research  •  2004  |  View Paper
During ischemia NMDG substitution increased glutamate and GABA efflux and choline enhanced the release of aspartate, glutamate, GABA and taurine.
Brain Research  •  1999  |  View Paper
They induced haemolysis in rat red blood cells and inhibited gamma amino butyric acid GABA ) and choline uptake into rat brain synaptosomes.
Toxicon : official journal of the International Society on Toxinology  •  1995  |  View Paper
This transporter is driven by the transmembrane Na+ gradient, as replacement of the extracellular Na+ by choline inhibits the GABA current.
Neuroreport  •  1994  |  View Paper
Kinetic analysis suggested that high affinity uptake systems exist for both GABA and choline , with apparent K m values of 0·5–1·0 μ m for GABA and 0·2–0·4 μ m for choline.
Experimental eye research  •  1982  |  View Paper
Use of choline as a Na + substitute depressed the effects of both muscimol and γ-aminobutyrate , although a preferential depression of muscimol responses was still apparent.
Neuroscience  •  1981  |  View Paper