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“Our study provides evidence that choline can depress population-level activity, quite likely by facilitating the release of GABA from interneurons, and may thereby influence hippocampal function.”
“ Choline enhanced in a concentration-dependent way the release of endogenous GABA but did not affect that of the radioactive aminoacid.”
“Thus the release of endogenously synthesized GABA (but not that of the aminoacid taken up) may be regulated by Ch through a mechanism involving penetration into the releasing terminal through a Ch uptake system.”
“Kinetic analysis suggested that high affinity uptake systems exist for both GABA and choline , with apparent K m values of 0·5–1·0 μ m for GABA and 0·2–0·4 μ m for choline.”
“Use of choline as a Na + substitute depressed the effects of both muscimol and γ-aminobutyrate , although a preferential depression of muscimol responses was still apparent.”