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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Choline and Eperisone



Research Papers that Mention the Interaction

Basic drugs such as eperisone , thiamine and scopolamine significantly inhibited choline uptake by the BBB with the half inhibitory concentration, IC50 value of 1.45, 2.06, and 0.47 mM, respectively.
Furthermore, eperisone inhibited competitively the uptake of choline with the inhibition constant, Ki value of 455 microM. According to these results it was suggested that in the BBB choline and basic drugs would share a common carrier-mediated transport system.
The uptake of choline by the isolated bovine brain capillaries was significantly inhibited by eperisone , scopolamine and thiamine in consistent with the in vivo results.
Journal of pharmacobio-dynamics  •  1990  |  View Paper