Possible Interaction: Choline and Dexamethasone

“1 μM Dexamethasone stimulates choline influx by 86% in normal cells and 36% in Alzheimer cells.”

“… choline … DM intake from 14.4 to 16.0 kg/d and, hence, net energy intake from 98.2 to 109.1 MJ/d at the … at 1 day in milk (DIM), but the effect of choline on milk protein yield gradually decreased during the course of the study.”

“Therefore, Dex affects radioactive Ch uptake in nerve endings and not in muscle fibres in the rat diaphragm.”

“It is significantly less when 0.2 microM Dex and 1 microM Ch are added to the medium.”

“Low concentrations of dexamethasone (up to 200 nM) increase the accumulation of choline (Ch) and its incorporation into acetylcholine (ACh) in the endplate rich area (EPA) of stimulated and unstimulated diaphragms in the presence of 10 microM Ch.”

“It seems probable that the increase of choline uptake in the ganglion induced by dexamethasone may, at least in part, occur in the preganglionic cholinergic terminals, leading to increased synthesis of acetylcholine.”

“Addition of 10(-9) M dexamethasone resulted in increased rates of choline incorporation per micrograms protein after both 6 and 12 days culture.”

“Although choline incorporation increases as a function of gestational age with a burst in rate on the last day of fetal life, dexamethasone suppresses this activity at all developmental ages past 19.5 days.”

“The data presented demonstrate a modest but significant increase in choline incorporation using a concentration of dexamethasone of 10 −9 M. At higher concentrations of dexamethasone, the incorporation was significantly depressed using an 8 day exposure time.”

“ Dexamethasone treatment of these animals for 6–12 hr led to enhanced choline incorporation rates.”