Possible Interaction: Choline and Deanol

“The results may indicate that radiolabeled choline and choline derivatives compete with a high concentration of the precursor dimethylaminoethanol , resulting in reduced uptake in small-rodent tumor models, a hypothesis that is currently under investigation in our laboratory.”

“Pretreatment, cotreatment, or delayed treatment with acetylcholine or choline prevented the adverse effects of DMAE.”

“Our data clearly demonstrates that, ethanolamine and N, N’-dimethyl ethanolamine showed 2-7 fold more uptake than choline.”

“ 2,2-Dimethylethanolamine and 2-methylethanolamine both reduced choline uptake to a greater extent than ethanolamine.”

“Apparently, however, dimethylaminoethanol was not precipitated by reineckate when pure and was only partially precipitated in the presence of choline.”

“Exposure to DMAE may affect choline uptake and synthesis.”

“A role for choline during early stages of mammalian embryogenesis … not been established, although recent studies show that inhibitors of choline uptake … metabolism, 2‐dimethylaminoethanol (DMAE), and 1‐O‐octadecyl‐2‐O‐methyl‐rac‐glycero‐3‐phosphocholine (…‐18‐OCH3), produce neural tube defects in mouse embryos grown in vitro.”

“Analogues of choline such as hemicholinium‐3, thiamine, ethanolamine and N N‐dimethylethanolamine inhibited choline unidirectional influx, whereas betaine and acetate had no effect.”

“Of a series of inhibitors and protectors, 2-dimethylaminoethanol was the most potent inhibitor of choline uptake and the most potent protector of both hematopoietic progenitor cells and murine L1210 leukemia cells.”

“These findings suggest that deanol increases the choline concentration in blood by inhibition of its metabolism in tissues.”

“Treatment with deanol also caused an increase in the concentration of choline in kidneys, and markedly inhibited the rates of oxidation and phosphorylation of intravenously administered [3H‐methyl]choline.”