Possible Interaction: Choline and Citicholine

“ Choline , a selective agonist at α7 receptors is increased with oral administration of cytidine 5'-diphosphocholine (CDP-choline), the cognitive effects of which were assessed in healthy volunteers.”

“ Citicoline increases choline availability for acetylcholine synthesis and membrane synthesis and repair.”

“Elevated DIC scores were attenuated by choline and blocked by CDP-choline.”

“injection of 200-600 micromol/kg of choline, CDP-choline or phosphocholine produced a dose-dependent increase in plasma glucagon and choline concentrations.”

“2 CDP-choline treatment caused several-fold increases in plasma concentrations of CDP-choline and its metabolites phosphocholine, choline , cytidine monophosphate (CMP) and cytidine.”

“ Choline levels in plasma, lateral cerebral ventricle and hypothalamus increased after CDP-choline administration.”

“ Choline levels in lateral cerebral ventricle and hypothalamus increased about nine- and fivefold, respectively, after CDP-choline (1 µmol) administration in normotensive rats.”

“Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine.”

“The results of the present work suggest that CDP-choline is acting by increasing choline levels in the cholinergic nerve terminals of the ICB, increasing the synthesis and/or release of ACh.”