Possible Interaction: Choline Chloride and Sodium Chloride

“Replacement of sodium chloride with choline chloride in the medium suppressed the uptake of AA.”

“However, when NaCl was substituted with choline chloride , a significant reduction in [3H]MPP+ uptake by Caco-2 and 293hEMT cells (of 56% and 68%, respectively) was observed.”

“Replacement of NaCl with choline chloride almost totally abolished the uptake.”

“Replacement of NaCl with choline chloride almost totally abolished the uptake.”

“Substitution of NaCl with choline chloride (120 mM) produced a marked suppression of AMPA-induced toxicity.”

“Moreover, this NMDA-selective neurotoxicity was critically dependent on the presence of a physiological extracellular sodium concentration, since the use of choline chloride instead of sodium chloride had a protective effect on dopaminergic neurons.”

“When choline chloride or N‐methyl‐D‐glucamine was used as the NaCl substitute, the amplitude of the action potential was slightly reduced (by 2‐5 mV) when the solution was changed 40 ms before the action potential was triggered.”

“Replacement of NaCl with choline chloride in the incubation medium also enhanced calcium uptake into brain tissue cytosol.”

“Replacement of entire NaCl with choline chloride markedly suppressed the mannitol-induced relaxation.”

“Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N‐methyl‐d‐glucamine HCl.”